CIN '2007 - 4th CONGRESS OF NEPHROLOGY IN INTERNET
Renal effects of Vitamin D analogs
Dr. Eva Rodríguez, Dr. Anna Oliveras, Dr. Clara Barrios, Dr. Mª José Soler, Dr. Josep Lloveras, and Dr. Daniel Batlle
Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois - Department of Nephrology, Hospital del Mar, Universidad Autonoma de Barcelona
Abstract
Vitamin D is a pleiotropic steroid hormone,that controls a broad range of metabolic and cell regulatory functions1. Vitamin D analogs are effective in the treatment and prevention of secondary hyperparathyroidism (SPHT) 2-4. In patients with chronic kidney disease (CKD) stages 3 and 4 paricalcitol has been found to reduce proteinuria 5. There is also evidence from experimental studies suggesting the Vitamin D may have renoprotective effects6. Activation of the vitamin D receptor has been shown to suppress renin7 .Therefore it is possible that some of the renal actions of vitamin D analogs such as reduction in proteinuria could be, at least in part, renin- mediated. Likewise, there are antihypertensive actions of vitamin D8 wich also may be related to inhibition of the renin-angiotensin-aldosterone system (RAAS).Comments: