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The journey from peritoneal dialysis to diabetic nephropathy: 3.4-DGE

Dra Beatriz Santamaria, Dra Ana Reyero y Dr Alberto Ortiz

Fundación Jiménez Díaz, Universidad Autónoma de Madrid y Grupo de Estudios Peritoneales de Madrid del Instituto Reina Sofia de Investigaciones Nefrológicas.- Madrid

Abstract

A high glucose concentration in the cell microenvironment is present in peritoneal dialysis (PD) and diabetes mellitus. This has led to the suggestion that high glucose may have a pathogenic role in cell and tissue injury in both entities. Glucose degradation products (GDPs) from PD solutions are considered key pathogenic molecules in cell injury. In particular, 3,4-di-deoxyglucosone-3-ene (3,4-DGE) accounted for most, if not all, the cytotoxicity of PD fluids against neutrophils and lymphocytes (1,2). Interestingly, 3,4-DGE also induces apoptosis in cells, such as renal epithelium, from organs that are targets of diabetes complications (1,2). This raises the possibility that apoptosis induction by glucose metabolites underlie the pathogenesis of some features of diabetic and PD tissue injury (1,2).

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