CIN '2007 - 4º CONGRESO DE NEFROLOGIA EN INTERNET
Obesity is associated with secondary hyperparathyroidism: a novel finding in Chronic Kidney Disease
Dr Csaba Kovesdy
Division of Nephrology, Salem Veterans Affairs Medical Center, Salem Virginia and of Medicine, University of Virginia, Charlottesville, Virginia.
Abstract
Obesity is associated with secondary hyperparathyroidism (SHPT) in the general population. It is unclear if the same association is present in patients with chronic kidney disease (CKD). We examined the association between intact PTH level and body mass index (BMI) in 496 male US veterans with CKD stage 2-5 not yet on dialysis by linear regression method. Higher PTH was associated with higher body mass index (BMI) after adjustment for age, race, diabetes mellitus, and serum calcium and phosphorus levels (adjusted geometric mean [95% CI] of PTH levels in patients with BMI <22, 22-28, 28.1-33 and >33 kg/m2: 84 [73-97], 92 [80-106], 102 [89-116] and 105 [92-120], p=0.008 for linear trend). The association was limited to patient groups with lower albumin (p=0.005 for the interaction term) or higher white blood cell count (p=0.026 for the interaction term). Higher BMI is associated with SHPT in patients with CKD who are not yet on dialysis, especially in patients with evidence of malnutrition and inflammation.Comentarios :