CIN '2007 - 4o CONGRESSO DE NEFROLOGIA NA INTERNET

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Influence of advanced Glycation End Products (AGEs) on Podocytes

Dr Christiane Ruester and Dr Gunter Wolf

Friedrich Schiller University Jena.

Abstract

Podocyteinjury with loss of cells into the urine seems to be an early factor in diabetic nephropathy. Advanced glycationend-products (AGEs) are important mediators of structural and functional renal abnormalities in diabetic nephropathy. AGE-mediated effects on podocytepathophysiologyin diabetic nephropathy remain incompletely resolved.

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